Orally -Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer. Suriyan Ponnusamy and Ramesh Narayana et al (2019). Clinical Cancer Research
Sprague Dawley Rag2 null rats created from engineered spermatogonial stem cells are immunodeficient and permissive to human xenografts. Fallon K Noto, Valeriya Adjan Steffey, Min Tong, Kameswaran Ravichandran, Wei Zhang, Angela Arey, Christopher B McClain, Eric Ostertag, Sahar Mazhar, Jaya Sangodkar, AnalisaDifeo, Jack Crawford, Goutham Narla and Tseten Y Jamling.
Local Injection of Submicron Particle Docetaxel is Associated with Tumor Eradication, Reduced Systemic Toxicity and an Immunologic Response in Uro-Oncologic Xenografts. Maulhardt, H. A., Hylle, L., Frost, M. V., Tornio, A., Dafoe, S., Drummond, L., … diZerega, G. S. (2019). Local Injection of Submicron Particle Docetaxel is Associated with Tumor Eradication, Reduced Systemic Toxicity and an Immunologic Response in Uro-Oncologic Xenografts. Cancers, 11(4), 577. doi:10.3390/cancers11040577
Hera’s talk at Scientist.com on using the SRG rat for the 3Rs. Dr. TY Jamling, VP of Hera BioLabs joins other experts on the Scientist.com webinar and focuses on how Hera’s SRG rat can reduce the amount of animals used in oncology studies in comparison to mice.
2019 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. A Rag2/Il2rg double-knockout rat supports engraftment of human immune system for immunotherapy-based cancer efficacy studies.
2018 American Association for Cancer Research (AACR) Annual Meeting poster. The SRG™ rat: A novel SCID rat for humanization studies
2017 American Association for Cancer Research (AACR) Annual Meeting poster A Novel Immunodeficient Rat for Modeling Human Cancer
2017 American Association for Cancer Research (AACR) Advances in Modeling Cancer in Mice. Novel immunodeficient rat models capable of supporting the growth of human tumor xenografts. This poster includes ovarian patient derived xenograft or PDX model data in OncoRat SRG and NSG mice.
2017 AACR-EORTC-NCI Molecular Targets poster Novel immunodeficient rat models offers a unique platform for drug efficacy studies in human tumor xenografts.
2018 AACR Spotlight Theater Presentation. OncoRat SRG: A new Rag2/Il2rg SCID rat enabling cell line xenografts, accelerating PDX establishment, humanizing the immune system