• Hera Presents at SOT 2017 & AACR 2017 Recap - Hera strives to provide its clients with superior preclinical toxicology and efficacy research from model creation to data delivery.  Below are the summaries of our presentations from the Society of Toxicology – Annual Meeting 2017 and the American Association for Cancer Research – Annual Meeting 2017. Effect of Transfecting HepG2 with Human CYP Enzymes on Chemical Toxicity (SOT 2017) HepG2,… Continue Reading >
  • Bacterial Carriers Offer New Hope in the Treatment of Glioblastoma - Unlike many cancers, which have seen a tremendous increase in effective treatment options and, as a result, an increase in survival rates, the prognosis for patients diagnosed with glioblastoma (GBM) brain tumors remains pretty bleak. One of the biggest challenges associated with GBM is the fact that the blood-brain barrier prevents efficient drug dosing to tumors through traditional methods. Viral… Continue Reading >
  • Rat Models Provide Superior Insights into Mutagenic/Carcinogenic Responses in Humans - Although in-vitro bacterial mutation assays and murine models have long been the gold standard for identifying DNA reactive genotoxic chemicals, the Ames Test method (as this is widely known) has significant limitations, which is why many researchers are now turning to transgenic rat models for toxicological studies. This is because the rat model offers numerous advantages over its mouse counterparts:… Continue Reading >
  • Chimeric Humanized Mouse Models: Understanding Human and Mouse Cell Interactions - Humanized liver mouse models are increasingly being used in preclinical trials and have allowed for groundbreaking in-vivo research to evaluate everything from human-specific drug toxicity and efficacy to gene therapies. Unlike their transgenic mouse model counterparts, chimeric liver mouse models that include human hepatocytes and it is important for researchers to better understand the interactions between the implanted human cells… Continue Reading >
  • Transposon Mutagenesis Helps Identify Genes Mediating Drug Resistance in the Treatment of CLL - First time treatment of Chronic Lymphocratic Leukemia (CLL) generally requires a chemotherapy regimen that includes fludarabine. And although this potent drug combination has an astounding overall response rate of more than 90%, the unfortunate reality is that most patience will eventually relapse. And even more concerning is that in addition to the relatively small percentage of patients who are inherently… Continue Reading >
  • PDX Models of Lung Cancer Closely Mimic Characteristics of Patient Primary Tumors - Despite ongoing research, lung cancers have remained among the most difficult to treat and account for the greatest number of cancer-related deaths worldwide. A suspected reason is the underlying molecular complexity of individual malignancies. Non-small cell lung cancers (NSCLC) account for approximately 85% of all lung cancers, yet research shows that these NSCLC tumors rarely share common cancer driver mutations,… Continue Reading >
  • Rat Provides a More Robust & Convenient Animal Infection Model for Hepatitis E Virus - Continue Reading >
  • Orthoptopic vs. Subcutaneous Xenograft Models of Human PC-3 Prostate Cancer - Subcutaneously implanted patient-derived xenografts (PDX) have become a commonly used tool in the study of cancer; however, these PDX models rarely metastasize from the subcutaneous site – even if the original patient tumors are known to be metastatic. Orthotopic xenograft models, on the other hand, seem to more closely mimic the metastases observed in human prostate cancer patients, according to… Continue Reading >
  • HIV-1 Gene Therapies Considered: RNAi versus CRISPR-cas - Though human immunodeficiency virus type 1 (HIV-1) can now be effectively treated to prevent disease progression through the use of potent antiviral drugs, decades after this disease’s discovery, there still is no cure for this precursor to acquired immune deficiency syndrome, also known as AIDS. In a recent article published in the journal Biochemical Society Transactions by Herrera-Carrillo and Berkhout… Continue Reading >
  • Transgenic Rats as Research Models Boast Significant Benefits…. - Transgenic Rats as Research Models Boast Significant Benefits over Mouse Counterparts Though much of today’s rodent-based research is performed using mouse models, the reality is that if we look back, many of the most impactful physiology, neurophysiology and neuroscience studies, including much of the Nobel Prize-winning place cell work, were historically done in rats. As murine research becomes increasingly sophisticated,… Continue Reading >