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Hera Biolabs to present at the 2018 AACR Annual Meeting.-Hera Biolabs will be presenting xenograft, PDX, and humanization of the immune system data from our new immunodeficient OncoRat SRG model at the up coming AACR 2018 Annual Meeting. POSTER: Title: The SRG Rat™: A novel SCID rat for humanization studies Title: Translational Therapeutics in Cancer Models 1 Date and Time: Monday Apr 16, 2018 8:00 AM – 12:00 PM… Continue Reading >
Understanding Transporter-Mediated Drug-Drug Interactions Using Humanized Liver Mice-Pharmaceutical researchers and regulators are increasingly aware of the influence that transporters have on the pharmacokinetics of drugs. These transporter mediated drug-drug interactions (DDIs) can precipitate adverse reactions in patients and as a result, safety guidelines across the United States, Europe and Japan have been updated to require safety assessments of DDIs in large scale clinical trials of pharmaceuticals. … Continue Reading >
Using Patient Derived Xenografts to Improve Therapeutic Cancer Treatments-An increased understanding of human tumors has created a solid foundation for the creation of new anti-cancer treatments (many of which involve antineoplastic compounds). And while many of these newly conceived drug therapies show profound responses in preclinical trials, this has not translated into significant progress in the clinical setting. In fact, less than 5% of such treatments showed efficacy… Continue Reading >
Humanized immune-system SRG Rats™ & mice for immuno-oncology-The SRG rat demonstrates robust immune-system humanization with peripheral blood mononuclear cells, the huPBMC-SRG rat™. First published in Hera's 2017 AACR-EORTC-NCI Molecular Targets poster Novel immunodeficient rat models offers a unique platform for drug efficacy studies in human tumor xenografts. Humanized SRG rats may have advantages in immuno-oncology, in particular for tumor models with low take-rates in mice. Hera is… Continue Reading >
Using Cell Sheet Technique to Study the Development of HCC in Rat Models-As the single most prevalent primary liver cancer and the third leading cause of cancer related deaths worldwide, a hepatocellular carcinoma (HCC) diagnosis presents patients with an exceedingly poor long-term prognosis. Currently there are no known treatments, and as such, biomedical researchers continue to look for new effective therapies. In a recent study by Alshareeda, et al published in… Continue Reading >
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